In Type IV hyperlipoproteinemia, which lipoprotein fraction is increased?

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Study for the Bishop Clinical Chemistry Test. Engage with flashcards and multiple choice questions with hints and explanations to prepare thoroughly for your exam!

Multiple Choice

In Type IV hyperlipoproteinemia, which lipoprotein fraction is increased?

Explanation:
Type IV hyperlipoproteinemia shows excess production or decreased clearance of very-low-density lipoprotein (VLDL), which carries triglycerides. In electrophoresis, VLDL migrates in the pre-beta region, so the pre-beta-lipoprotein fraction is elevated. Chylomicrons would dominate only in types I and V, LDL corresponds to beta-lipoprotein, and HDL corresponds to alpha-lipoprotein and is not the feature driving Type IV. So the lipoprotein fraction that's increased is the pre-beta-lipoprotein, reflecting the elevated VLDL.

Type IV hyperlipoproteinemia shows excess production or decreased clearance of very-low-density lipoprotein (VLDL), which carries triglycerides. In electrophoresis, VLDL migrates in the pre-beta region, so the pre-beta-lipoprotein fraction is elevated. Chylomicrons would dominate only in types I and V, LDL corresponds to beta-lipoprotein, and HDL corresponds to alpha-lipoprotein and is not the feature driving Type IV. So the lipoprotein fraction that's increased is the pre-beta-lipoprotein, reflecting the elevated VLDL.

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