LD isoenzyme analysis helps distinguish damage to which tissues?

LD isoenzyme analysis helps distinguish damage to which tissues?

• A. Heart, liver, and skeletal muscle
• B. Brain and kidney
• C. Pancreas
• D. Lungs

Answer: (A)

Lactate dehydrogenase comes in several isoenzymes, each with a characteristic distribution in different tissues. When tissue is damaged, the corresponding isoenzymes spill into the bloodstream, and the pattern of which isoenzymes are elevated points to the tissue of origin. The heart has a prominent LDH-1 form, while the liver and skeletal muscle show higher LDH-5 activity, and the lungs favor LDH-3. Because of these patterns, LD isoenzyme analysis helps distinguish damage to heart, liver, and skeletal muscle most clearly.

Lactate dehydrogenase comes in several isoenzymes, each with a characteristic distribution in different tissues. When tissue is damaged, the corresponding isoenzymes spill into the bloodstream, and the pattern of which isoenzymes are elevated points to the tissue of origin. The heart has a prominent LDH-1 form, while the liver and skeletal muscle show higher LDH-5 activity, and the lungs favor LDH-3. Because of these patterns, LD isoenzyme analysis helps distinguish damage to heart, liver, and skeletal muscle most clearly.